Particle swarm optimization approach for protein structure prediction in the 3D HP model
The primary structure of proteins consists of a linear chain of amino acids that can vary in length. Proteins fold, under the influence of several chemical and physical factors, into their 3D structures, which determine their biological functions and properties. Misfolding occurs when the protein fo...
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| Format: | article |
| Published: |
2012
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| Online Access: | http://hdl.handle.net/10725/2957 http://dx.doi.org/10.1007/s12539-012-0131-z http://link.springer.com/article/10.1007/s12539-012-0131-z |
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| Summary: | The primary structure of proteins consists of a linear chain of amino acids that can vary in length. Proteins fold, under the influence of several chemical and physical factors, into their 3D structures, which determine their biological functions and properties. Misfolding occurs when the protein folds into a 3D structure that does not represent its native structure, which can lead to diseases. Due to the importance of this problem and since laboratory techniques are not always feasible, computational methods for characterizing protein structures have been proposed. In this paper, we present a particle swarm optimization (PSO) based algorithm for predicting protein structures in the 3D hydrophobic polar model. Starting from a small set of candidate solutions, our algorithm efficiently explores the search space and returns 3D protein structures with minimal energy. To test our algorithm, we used two sets of benchmark sequences of different lengths and compared our results to published results. Our algorithm performs better than previous algorithms by finding lower energy structures or by performing fewer numbers of energy evaluations. |
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