Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts ROLE IN SUPPRESSION OF c/EBP/NF-κB-MEDIATED MEKK1-INDUCED MMP-1 EXPRESSION
Cyclooxygenase-2 (COX-2) overexpression has been linked to cell survival, transformation, and hyperproliferation. We examined the regulation of the tumor suppressor gene p53 and p53 target genes by prostaglandin E2 (PGE2) in human synovial fibroblasts (HSF). PGE2 induced a time-dependent increase in...
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| Other Authors: | , , , , |
| Format: | article |
| Published: |
2006
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| Online Access: | http://hdl.handle.net/10725/2316 http://dx.doi.org/10.1074/jbc.M601293200 http://www.jbc.org/content/281/29/19849.short |
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