A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells

urpose Activation of STAT3 has been identified as a central mediator of melanoma growth and metastasis. We hypothesized that WP1066, a novel STAT3 blockade agent, has marked antitumor activity, even against the melanoma metastasis to brain, a site typically refractory to therapies. Experimental Desi...

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Bibliographic Details
Main Author:	Abou-Ghazal, Mohamed K. (author)
Other Authors:	Kong, Ling-Yuan (author), Wei, Jun (author), Chakraborty, Arup (author), Qiao, Wei (author), Fuller, Gregory N. (author), Fokt, Izabela (author), Grimm, Elizabeth A. (author), Schimttling, Robert J. (author), Archer, Gary E. (author), Sampson, John H. (author), Priebe, Waldemar (author), Heimberger, Amy B. (author)
Format:	article
Published:	2008
Online Access:	http://hdl.handle.net/10725/6478 http://dx.doi.org/10.1158/1078-0432.CCR-08-0377 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583362/
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A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells

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