PGE2 induces COX-2 expression in podocytes via the EP4 receptor through a PKA-independent mechanism
Cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2) synthesis correlates with the onset of proteinuria and increased glomerular capillary pressure (Pgc) glomerular disease models. We previously showed that an in vitro surrogate for Pgc (cyclical mechanical stretch) upregulates the expression...
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| Format: | article |
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2008
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| Online Access: | http://hdl.handle.net/10725/2318 http://dx.doi.org/10.1016/j.cellsig.2008.08.007 http://www.sciencedirect.com/science/article/pii/S0898656808002350 |
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