A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

Novel agents to treat acute myeloid leukemia (AML) are needed with increased efficacy and specificity. We have synthesized a dual-specificity fusion toxin DTU2GMCSF composed of the catalytic and translocation domains of diphtheria toxin (DT) fused to the granulocyte-macrophage colony-stimulating fac...

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Bibliographic Details
Main Author: Abi-Habib, Ralph J. (author)
Other Authors: Lui, Shihui (author), Bugge, Thomas (author), Leppla, Stephen H. (author), Frankel, Arthur (author)
Format: article
Published: 2004
Online Access:http://hdl.handle.net/10725/2732
http://dx.doi.org/10.1182/blood-2004-01-0339
http://www.bloodjournal.org/content/104/7/2143.full.pdf+html?sso-checked=true
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http://hdl.handle.net/10725/2732
http://dx.doi.org/10.1182/blood-2004-01-0339
http://www.bloodjournal.org/content/104/7/2143.full.pdf+html?sso-checked=true

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