Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells

DT388GMCSF, a fusion toxin composed of the NH2-terminal region of diphtheria toxin (DT) fused to human granulocyte-macrophage colony-stimulating factor (GMCSF) has shown efficacy in the treatment of acute myeloid leukemia. However, the primary dose-limiting side effect is liver toxicity. We have rep...

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Bibliographic Details
Main Author:	Abi-Habib, Ralph J. (author)
Other Authors:	Westcott, Marlena (author), Cohen, Kimberley (author), Willingham, Mark (author), Lui, Shihui (author), Bugge, Thomas (author), Leppla, Stephen H. (author), Frankel, Arthur (author)
Format:	article
Published:	2004
Online Access:	http://hdl.handle.net/10725/2736 http://mct.aacrjournals.org/content/3/12/1681.short
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