Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of epidermal growth factor receptor
Platelet-derived growth factor (PDGF) receptor (PDGFR) expression correlates with metastatic medulloblastoma. PDGF stimulation of medulloblastoma cells phosphorylates extracellular signal-regulated kinase (ERK) and promotes migration. We sought to determine whether blocking PDGFR activity effectivel...
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2009
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| Online Access: | http://hdl.handle.net/10725/4423 http://dx.doi.org/10.1158/1535-7163.MCT-08-088 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://mct.aacrjournals.org/content/8/5/1137 |
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