Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells

In this study, we target arginine auxotrophy of AML cell lines using human arginase I cobalt-PEG5000. HuArgI(Co)-PEG5000 was cytotoxic to all AML cell lines tested. Mononuclear cells and CD34+ blasts were not sensitive demonstrating the selectivity of HuArgI(Co)-PEG5000-induced arginine deprivation....

Full description

Saved in:
Bibliographic Details
Main Author: Bekdash, Amira (author)
Other Authors: Abi-Habib, Ralph J. (author), Tanios, Rita (author), Stone, Everett (author), Georgiou, Georges (author), Frankel, Arthur E. (author), Kassab, Elias (author)
Format: article
Published: 2013
Online Access:http://hdl.handle.net/10725/2741
http://dx.doi.org/10.1016/j.leukres.2013.08.007
http://www.sciencedirect.com/science/article/pii/S0145212613002889
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://hdl.handle.net/10725/2741
http://dx.doi.org/10.1016/j.leukres.2013.08.007
http://www.sciencedirect.com/science/article/pii/S0145212613002889

Similar Items