P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis

The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with little therapeutics available: riluzole is the only drug ap...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Milane, Aline (author)
مؤلفون آخرون: Fernandez, Christine (author), Dupuis, Luc (author), Buyse, Marion (author), Loeffler, Jean-Philippe (author), Farinotti, Robert (author), Meininger, Vincent (author), Bensimon, Gilbert (author)
التنسيق: article
منشور في: 2010
الوصول للمادة أونلاين:http://hdl.handle.net/10725/4497
http://dx.doi.org/10.1016/j.neulet.2010.01.078
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
http://www.sciencedirect.com/science/article/pii/S030439401000131X
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