Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity

Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity

Native proaerolysin is a channel-forming bacterial protoxin that binds to cell-surface receptors and then is activated by furin or furin-like proteases. We genetically engineered proaerolysin by replacing the furin-cleavage sequence with a prostate-specific antigen-selective sequence. The recombinan...

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Bibliographic Details
Main Author: Abi-Habib, Ralph (author)
Other Authors: Singh, Ravibhushan (author), Browning, Jeff L. (author), Wong, Kevin (author), Williams, Simon A. (author), Merchant, Rosemina (author), Denmeade, Samuel R. (author), Buckley, Thomas J. (author), Frankel, Arthur E. (author)
Format: article
Published: 2007
Online Access:http://hdl.handle.net/10725/2737
http://dx.doi.org/10.1097/CAD.0b013e3280bad82d
http://journals.lww.com/anti-cancerdrugs/Abstract/2007/08000/Recombinant_prostate_specific_antigen_proaerolysin.8.aspx
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http://hdl.handle.net/10725/2737
http://dx.doi.org/10.1097/CAD.0b013e3280bad82d
http://journals.lww.com/anti-cancerdrugs/Abstract/2007/08000/Recombinant_prostate_specific_antigen_proaerolysin.8.aspx

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