Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation

Blues brothers: Aggregation of the Tau protein is a key event in Alzheimer's disease and Tau aggregation inhibitors are important as potential drugs. Phenothiazines, such as methylene blue and its azure derivatives, have a unique mechanism, specifically modifying the Tau cysteine residues. The...

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Bibliographic Details
Main Author: Akoury, Elias (author)
Other Authors: Pickhardt, Marcus (author), Gajda, Michal (author), Biernat, Jacek (author), Mandelkow, Eckhard (author), Zweckstetter, Markus (author)
Format: article
Published: 2013
Online Access:http://hdl.handle.net/10725/10249
https://doi.org/10.1002/anie.201208290
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201208290
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