Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation
Blues brothers: Aggregation of the Tau protein is a key event in Alzheimer's disease and Tau aggregation inhibitors are important as potential drugs. Phenothiazines, such as methylene blue and its azure derivatives, have a unique mechanism, specifically modifying the Tau cysteine residues. The...
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2013
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| Online Access: | http://hdl.handle.net/10725/10249 https://doi.org/10.1002/anie.201208290 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201208290 |
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| _version_ | 1864513486224097280 |
|---|---|
| author | Akoury, Elias |
| author2 | Pickhardt, Marcus Gajda, Michal Biernat, Jacek Mandelkow, Eckhard Zweckstetter, Markus |
| author2_role | author author author author author |
| author_facet | Akoury, Elias Pickhardt, Marcus Gajda, Michal Biernat, Jacek Mandelkow, Eckhard Zweckstetter, Markus |
| author_role | author |
| dc.creator.none.fl_str_mv | Akoury, Elias Pickhardt, Marcus Gajda, Michal Biernat, Jacek Mandelkow, Eckhard Zweckstetter, Markus |
| dc.date.none.fl_str_mv | 2013 2019-03-21T14:41:22Z 2019-03-21T14:41:22Z 2019-03-21 |
| dc.identifier.none.fl_str_mv | 0368-1769 http://hdl.handle.net/10725/10249 https://doi.org/10.1002/anie.201208290 Akoury, E., Pickhardt, M., Gajda, M., Biernat, J., Mandelkow, E., & Zweckstetter, M. (2013). Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation. Angewandte Chemie International Edition, 52(12), 3511-3515. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201208290 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of the German Chemical Society |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Blues brothers: Aggregation of the Tau protein is a key event in Alzheimer's disease and Tau aggregation inhibitors are important as potential drugs. Phenothiazines, such as methylene blue and its azure derivatives, have a unique mechanism, specifically modifying the Tau cysteine residues. The modification keeps Tau in a monomeric disordered conformation preventing the formation of filaments and their toxic precursors. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_892c49deaebdf7bbf50ae896ab332157 |
| identifier_str_mv | 0368-1769 Akoury, E., Pickhardt, M., Gajda, M., Biernat, J., Mandelkow, E., & Zweckstetter, M. (2013). Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation. Angewandte Chemie International Edition, 52(12), 3511-3515. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10249 |
| publishDate | 2013 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregationAkoury, EliasPickhardt, MarcusGajda, MichalBiernat, JacekMandelkow, EckhardZweckstetter, MarkusBlues brothers: Aggregation of the Tau protein is a key event in Alzheimer's disease and Tau aggregation inhibitors are important as potential drugs. Phenothiazines, such as methylene blue and its azure derivatives, have a unique mechanism, specifically modifying the Tau cysteine residues. The modification keeps Tau in a monomeric disordered conformation preventing the formation of filaments and their toxic precursors.PublishedN/A2019-03-21T14:41:22Z2019-03-21T14:41:22Z20132019-03-21Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0368-1769http://hdl.handle.net/10725/10249https://doi.org/10.1002/anie.201208290Akoury, E., Pickhardt, M., Gajda, M., Biernat, J., Mandelkow, E., & Zweckstetter, M. (2013). Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation. Angewandte Chemie International Edition, 52(12), 3511-3515.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://onlinelibrary.wiley.com/doi/full/10.1002/anie.201208290enJournal of the German Chemical Societyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/102492021-03-19T10:45:22Z |
| spellingShingle | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation Akoury, Elias |
| status_str | publishedVersion |
| title | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation |
| title_full | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation |
| title_fullStr | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation |
| title_full_unstemmed | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation |
| title_short | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation |
| title_sort | Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation |
| url | http://hdl.handle.net/10725/10249 https://doi.org/10.1002/anie.201208290 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201208290 |