Penicillin-resistant streptococcus pneumoniae in Lebanon
A total of 123 clinical isolates of Streptococcus pneumoniae were collected from all over Lebanon and tested for their susceptibility to penicillin: 30.1% were susceptible (minimum inhibitory concentration (MIC) ≤ 0.06 μg/mL), 56.1% were intermediately susceptible (MIC 0.09–1.0 μg/mL) and 13.8% were...
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| Other Authors: | , , , |
| Format: | article |
| Published: |
2006
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| Online Access: | http://hdl.handle.net/10725/5205 http://dx.doi.org/10.1016/j.ijantimicag.2005.10.019 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0924857905003547 |
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| Summary: | A total of 123 clinical isolates of Streptococcus pneumoniae were collected from all over Lebanon and tested for their susceptibility to penicillin: 30.1% were susceptible (minimum inhibitory concentration (MIC) ≤ 0.06 μg/mL), 56.1% were intermediately susceptible (MIC 0.09–1.0 μg/mL) and 13.8% were resistant (MIC > 1.0 μg/mL). The oxacillin disk screening test detected all penicillin-resistant isolates, but erroneously designated two penicillin-intermediate isolates as penicillin susceptible. All isolates were consistently susceptible to levofloxacin, but cross-resistance between penicillin and the three tested cephalosporins was frequently noted. The in vitro activity of amoxicillin/clavulanic acid paralleled that of penicillin; however, 92.7% of the isolates were designated as susceptible based on the recommended interpretive cut-off point (MIC ≤ 2/1 μg/mL). This discrepancy represents a paradox that deserves serious consideration. |
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