Predicting Malignant Potential of Gastrointestinal Stromal Tumors Using Endoscopic Ultrasound
Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the GI tract arising from the interstitial cells of Cajal and stain positive for c-kit, a proto-oncogene protein. Approximately 5,000-6,000 cases are identified each year with approximately 30% of these lesions progressing...
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| Other Authors: | , , , |
| Format: | article |
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2007
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| Online Access: | http://hdl.handle.net/10725/4326 http://dx.doi.org/10.1016/j.gie.2007.03.404 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.giejournal.org/article/S0016-5107(07)00844-9/abstract |
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| Summary: | Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the GI tract arising from the interstitial cells of Cajal and stain positive for c-kit, a proto-oncogene protein. Approximately 5,000-6,000 cases are identified each year with approximately 30% of these lesions progressing to malignancy. The National Institutes of Health (NIH) has proposed defining risk of aggressive behavior of GISTs based on size of lesion and mitotic count. Endoscopic ultrasound (EUS) has been used in the evaluation of GISTs, but no EUS criteria exist to predict GISTs with high malignant potential. |
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