Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute myeloid leukemia
Anthrax lethal toxin (PrAg/LF) is a binary toxin consisting of protective antigen (PrAg), the cell binding moiety, and lethal factor (LF), the catalytic moiety. Inside the cell, LF cleaves MEKs and subsequently leads to the inhibition of the MAPK pathway causing cell death. Due to its off-target tox...
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| Format: | masterThesis |
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2023
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| Online Access: | http://hdl.handle.net/10725/15130 https://doi.org/10.26756/th.2023.615 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
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