Regulation of Class IA PI 3-kinases
We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 nSH2 and iSH2 domains that orients the nSH2 so as to inhibit p110α. We proposed...
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| Other Authors: | , , , , , , , , , |
| Format: | article |
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2009
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| Online Access: | http://hdl.handle.net/10725/2437 http://dx.doi.org/10.1073/pnas.0902369106 http://www.pnas.org/content/106/48/20258.short |
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