Regulation of Class IA PI 3-kinases
We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 nSH2 and iSH2 domains that orients the nSH2 so as to inhibit p110α. We proposed...
محفوظ في:
| المؤلف الرئيسي: | Wu, Haiyan (author) |
|---|---|
| مؤلفون آخرون: | Shekar, S. Chandra (author), Flinn, Rory J. (author), El-Sibai, Mirvat (author), Jaiswal, Bijay S. (author), Sen, K. Ilker (author), Janakiraman, Vasantharajan (author), Seshagiri, Somasekar (author), Gerfen, Gary J. (author), Girvin, Mark E. (author), Backer, Jonathan M. (author) |
| التنسيق: | article |
| منشور في: |
2009
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2437 http://dx.doi.org/10.1073/pnas.0902369106 http://www.pnas.org/content/106/48/20258.short |
| الوسوم: |
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