Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma
The small molecule inducers of TRAIL ONC201/TIC10 and its analog ONC206 exhibit anti-tumor activity by inhibiting AKT/ERK phosphorylation and causing early activation of the integrated stress response. They are reported to inhibit the DRD2 receptors and activate mitochondrial ClpP leading to apoptos...
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| Format: | masterThesis |
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2020
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| Online Access: | http://hdl.handle.net/10725/13447 https://doi.org/10.26756/th.2022.334 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
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