Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1

In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primary AML blasts using PrAgU2/LF, a urokinase-activated anthrax lethal toxin. PrAgU2/LF was cytotoxic to five out of nine AML...

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Main Author: Nasser, Selim (author)
Other Authors: Ghanem, Hadi (author), Abi-Habib, Ralph J. (author), Bekdash, Amira (author), Darwish, Manal (author), Timsah, Zahra (author), Najjar, Vicky (author), Ghosn, Marwan (author), El-Hajj, Hiba (author), Bazerbachi, Ali (author), Liu, Shihui (author), Leppla, Stephen H. (author), Frankel, Arthur E. (author), Kassab, Elias (author)
Format: article
Published: 2015
Online Access:http://hdl.handle.net/10725/5149
http://dx.doi.org/10.1016/j.tranon.2015.07.001
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
http://www.sciencedirect.com/science/article/pii/S1936523315000571
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