The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal microtubule (MT)-associated protein that functions to maintain MT stability, is implicated in a number of hereditary and sporadic neurodegenerative diseases including frontotemporal dementia and Alzheimer&...
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| Format: | article |
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2015
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| Online Access: | http://hdl.handle.net/10725/10252 https://doi.org/10.1093/hmg/ddv135 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/hmg/article/24/14/3971/2385773 |
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