Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-α gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts
Tumor necrosis factor-α (TNF-α) is a pleiotropic proinflammatory cytokine that modulates a broad range of inflammatory and immunological processes. We have investigated the potential immunomodulatory properties of prostaglandin E2 (PGE2) by examining the molecular mechanism by which the eicosanoid s...
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| Other Authors: | , , , , |
| Format: | article |
| Published: |
2005
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| Online Access: | http://hdl.handle.net/10725/2314 http://dx.doi.org/10.1074/jbc.M414067200 http://www.jbc.org/content/280/10/9536.short |
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