Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breast Cancer
Wild type Anthrax Lethal toxin is a binary toxin comprised of a protective antigen (PrAg), the cell binding moiety and a lethal factor (LF), the catalytic moiety. Following cell entry, LF cleaves all mitogen- activated protein kinase kinase (MEKs) leading to the inactivation of the MAPK pathway. PrA...
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| Format: | masterThesis |
| Published: |
2023
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| Online Access: | http://hdl.handle.net/10725/15836 https://doi.org/10.26756/th.2023.680 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
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