Characterization of the Cytotoxic Mechanism and Mode of Cell Death Induced by a MEK1/2-selective version of Anthrax Lethal Toxin (PrAg/LFW271A) in Acute Myeloid Leukemia

Wild-type anthrax lethal toxin (PrAg/LF) demonstrated high potency in inhibiting the MAPK pathway in AML cell lines that rely on this pathway for survival. PrAg/LF is a binary toxin consisting of protective antigen (PrAg), that serves as the tumor specific delivery protein, and the wild-type effecto...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Mroue, Zeinab (author)
التنسيق:	masterThesis
منشور في:	2023
الموضوعات:	Acute myeloid leukemia > Pathogensis Mitogen-activated protein kinases Protein kinases > Inhibitors Autophagic vacuoles Lebanese American University > Dissertations Dissertations, Academic
الوصول للمادة أونلاين:	http://hdl.handle.net/10725/15083 https://doi.org/10.26756/th.2023.584 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
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Characterization of the Cytotoxic Mechanism and Mode of Cell Death Induced by a MEK1/2-selective version of Anthrax Lethal Toxin (PrAg/LFW271A) in Acute Myeloid Leukemia

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