Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator‐activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: Evidence for receptor antagonism

Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator‐activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: Evidence for receptor antagonism

Objective To characterize the inhibitory effects of therapeutic concentrations of the nonsteroidal antiinflammatory drug nimesulide (NIM) on peroxisome proliferator-activated receptor (PPAR)-induced cyclooxygenase 2 (COX-2) gene expression in human synovial fibroblasts (HSFs) from patients with oste...

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Bibliographic Details
Main Author: Faour, Wissam (author)
Other Authors: Kalajdzic, Tanja (author), He, Qing Wen (author), Fahmi, Hassan (author), Martel-Pelletier, Johanne (author), Pelletier, Jean-Pierre (author), Di Battista, John (author)
Format: article
Published: 2002
Online Access:http://hdl.handle.net/10725/2315
http://dx.doi.org/10.1002/art.10055
http://onlinelibrary.wiley.com/doi/10.1002/art.10055/full
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