RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

Rho GTPases are versatile regulators of cell shape that act on the actin cytoskeleton. Studies using Rho GTPase mutants have shown that, in some cells, Rac1 and Cdc42 regulate the formation of lamellipodia and filopodia, respectively at the leading edge, whereas RhoA mediates contraction at the rear...

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Main Author: El-Sibai, Mirvat (author)
Other Authors: Pertz, Olivier (author), Pang, Huan (author), Yip, Shu-Chin (author), Lorenz, Mike (author), Symons, Marc (author), Condeelis, John S. (author), Hahn, Klaus M. (author), Backer, Jonathan M. (author)
Format: article
Published: 2008
Online Access:http://hdl.handle.net/10725/2440
http://dx.doi.org/10.1016/j.yexcr.2008.01.016
http://www.ncbi.nlm.nih.gov/pubmed/18316075
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http://hdl.handle.net/10725/2440
http://dx.doi.org/10.1016/j.yexcr.2008.01.016
http://www.ncbi.nlm.nih.gov/pubmed/18316075

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