Role of PDE3 and PDE4 for β-adrenergic control of cAMP and ICa,L in adult rat ventricular myocytes

Role of PDE3 and PDE4 for β-adrenergic control of cAMP and ICa,L in adult rat ventricular myocytes

β-Adrenergic stimulation increases cAMP in cardiac cells to induce PKA-mediated phosphorylation of various proteins regulating heart function, such as the L-type Ca 2+ channels which carry I Ca,L and trigger cardiac contraction. Phosphodiesterases (PDEs) 3 and 4 are the main cAMP degrading enzymes i...

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Bibliographic Details
Main Author: Leroy, Jerome (author)
Other Authors: Abi-Gerges, Aniella (author), Richter, Wito (author), Nikolaev, Viacheslav O. (author), Engelhardt, Stefan (author), Lohse, Martin J. (author), Conti, Marco (author), Fischmeister, Rodolphe (author), Vandecasteele, Gregoire (author)
Format: article
Published: 2007
Online Access:http://hdl.handle.net/10725/6362
http://dx.doi.org/10.1117/j.yjmcc.2007.03.139
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.jmmc-online.com/article/S0022-2828(07)00195-2/abstract#articleInformation
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http://hdl.handle.net/10725/6362
http://dx.doi.org/10.1117/j.yjmcc.2007.03.139
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.jmmc-online.com/article/S0022-2828(07)00195-2/abstract#articleInformation

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