A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

Urokinase plasminogen activator (uPA) is a tumor-specific protease highly expressed in several types of solid tumors and rarely present on normal cells under physiologic conditions. Due to its high expression on metastatic tumors, several different strategies have been used to target the urokinase s...

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Bibliographic Details
Main Author: Abi-Habib, Ralph J. (author)
Other Authors: Singh, Ravibhushan (author), Liu, Shihui (author), Bugge, Thomas (author), Leppla, Stephen H. (author), Frankel, Arthur (author)
Format: article
Published: 2006
Online Access:http://hdl.handle.net/10725/2744
http://dx.doi.org/ 10.1158/1535-7163.MCT-06-0315
http://mct.aacrjournals.org/content/5/10/2556.short
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