Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibroblasts
The p38 MAPK mediates transcriptional and post-transcriptional control of cyclooxygenase-2 (COX-2) mRNA following interleukin-1(IL-1)/lipopolysaccharide cellular activation. We explored a positive feedback, prostaglandin E2 (PGE2)-dependent stabilization of COX-2 mRNA mediated by the p38 MAPK cascad...
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
2001
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| Online Access: | http://hdl.handle.net/10725/2311 http://dx.doi.org/10.1074/jbc.M104036200 http://www.jbc.org/content/276/34/31720.short |
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