Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice
Purpose: Anthrax Lethal Toxin (LeTx), composed of protective antigen and lethal factor, catalytically cleaves mitogen-activated protein kinase (MAPK) kinases and inhibits the MAPK signaling pathways. The majority of metastatic melanomas possess the V599E BRAF mutation, which constitutively activates...
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| Other Authors: | , , , , , , |
| Format: | article |
| Published: |
2006
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| Online Access: | http://hdl.handle.net/10725/2735 http://dx.doi.org/ 10.1158/1078-0432.CCR-06-2019 http://www.ncbi.nlm.nih.gov/pubmed/17189417 |
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