Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice
Purpose: Anthrax Lethal Toxin (LeTx), composed of protective antigen and lethal factor, catalytically cleaves mitogen-activated protein kinase (MAPK) kinases and inhibits the MAPK signaling pathways. The majority of metastatic melanomas possess the V599E BRAF mutation, which constitutively activates...
محفوظ في:
| المؤلف الرئيسي: | Abi-Habib, Ralph J. (author) |
|---|---|
| مؤلفون آخرون: | Singh, Ravibhushan (author), Leppla, Stephen H. (author), Greene, John J. (author), Ding, Yan (author), Berghuis, Bree (author), Duesbery, Nicholas S. (author), Frankel, Arthur E. (author) |
| التنسيق: | article |
| منشور في: |
2006
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2735 http://dx.doi.org/ 10.1158/1078-0432.CCR-06-2019 http://www.ncbi.nlm.nih.gov/pubmed/17189417 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
مواد مشابهة
-
Sensitivity of colorectal cancer cells to the recombinant Anthrax lethal toxin and the Urokinase-activated Anthrax lethal toxin. (c2014)
حسب: Kasbo, Zein Jean
منشور في: (2014) -
BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin
حسب: Abi-Habib, Ralph J.
منشور في: (2005) -
Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity
حسب: Abi-Habib, Ralph J.
منشور في: (2013) -
A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types
حسب: Abi-Habib, Ralph J.
منشور في: (2006) -
Effect of Anthrax Lethal Toxin on Activation of MAPK Pathway and Autophagy in AML Cell Lines
حسب: Soukarieh, Rania
منشور في: (2021)