Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping

Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping

<p dir="ltr">Proteogenomics studies generate hypotheses on protein function and provide genetic evidence for drug target prioritization. Most previous work has been conducted using affinity-based proteomics approaches. These technologies face challenges, such as uncertainty regarding...

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Main Author: Karsten Suhre (67967) (author)
Other Authors: Guhan Ram Venkataraman (9009668) (author), Harendra Guturu (451866) (author), Anna Halama (545988) (author), Nisha Stephan (17445912) (author), Gaurav Thareja (459188) (author), Hina Sarwath (4480654) (author), Khatereh Motamedchaboki (266248) (author), Margaret K. R. Donovan (12161084) (author), Asim Siddiqui (25153) (author), Serafim Batzoglou (2585) (author), Frank Schmidt (207186) (author)
Published: 2024
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Pharmacology and pharmaceutical sciences
Proteogenomics
Peptide-centric analysis
Affinity-based proteomics
Drug target prioritization
Cis-protein associations
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