Functional Characterization of Novel <i>MC4R </i>Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Functional Characterization of Novel <i>MC4R </i>Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

<p dir="ltr">The leptin–melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The <i>MC4R</i> gene plays a central role in leptin–melanocortin signaling,...

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Bibliographic Details
Main Author: Idris Mohammed (751020) (author)
Other Authors: Senthil Selvaraj (314873) (author), Wesam S. Ahmed (10170053) (author), Tara Al-Barazenji (18002491) (author), Ayat S Hammad (19437820) (author), Hajar Dauleh (18002500) (author), Luis R. Saraiva (18282274) (author), Mashael Al-Shafai (3466301) (author), Khalid Hussain (110443) (author)
Published: 2023
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Medical biochemistry and metabolomics
MC4R
monogenic obesity
severe obesity
childhood obesity
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