Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis

Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis

<p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motor neurons (MNs). There are no effective treatments and patients usually die within 2–5 years of diagnosis. Emerging commonalities between familial and sporadic cases of this complex mul...

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Bibliographic Details
Main Author: Sophie Hawkins (18421377) (author)
Other Authors: Seema C. Namboori (11031624) (author), Ammarah Tariq (18421380) (author), Catherine Blaker (18421383) (author), Christine Flaxman (18421386) (author), Nidhi S. Dey (18421389) (author), Peter Henley (16296524) (author), Andrew Randall (2601499) (author), Alessandro Rosa (470248) (author), Lawrence W. Stanton (6707191) (author), Akshay Bhinge (173004) (author)
Published: 2022
Subjects:
Biological sciences
Biochemistry and cell biology
Genetics
ALS
microRNA
miR-139
WNT
FUS
sporadic
iPSC
motor neurons
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