Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells

Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells

<p>Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggere...

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Bibliographic Details
Main Author: Shilpa Kuttikrishnan (3520079) (author)
Other Authors: Ajaz A. Bhat (12984701) (author), Jericha M. Mateo (17563293) (author), Fareed Ahmad (134672) (author), Feras Q. Alali (2691907) (author), Tamam El-Elimat (694398) (author), Nicholas H. Oberlies (326437) (author), Cedric J. Pearce (1364220) (author), Shahab Uddin (154400) (author)
Published: 2022
Subjects:
Biological sciences
Biochemistry and cell biology
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Oncology and carcinogenesis
Natural products
Meroterpenoids
Fungal secondary metabolites
Neosetophomone B
Apoptosis
Leukemia
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