Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
<p>Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggere...
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2022
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| _version_ | 1864513535810207744 |
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| author | Shilpa Kuttikrishnan (3520079) |
| author2 | Ajaz A. Bhat (12984701) Jericha M. Mateo (17563293) Fareed Ahmad (134672) Feras Q. Alali (2691907) Tamam El-Elimat (694398) Nicholas H. Oberlies (326437) Cedric J. Pearce (1364220) Shahab Uddin (154400) |
| author2_role | author author author author author author author author |
| author_facet | Shilpa Kuttikrishnan (3520079) Ajaz A. Bhat (12984701) Jericha M. Mateo (17563293) Fareed Ahmad (134672) Feras Q. Alali (2691907) Tamam El-Elimat (694398) Nicholas H. Oberlies (326437) Cedric J. Pearce (1364220) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shilpa Kuttikrishnan (3520079) Ajaz A. Bhat (12984701) Jericha M. Mateo (17563293) Fareed Ahmad (134672) Feras Q. Alali (2691907) Tamam El-Elimat (694398) Nicholas H. Oberlies (326437) Cedric J. Pearce (1364220) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2022-04-23T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.bbrc.2022.02.071 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Anticancer_activity_of_Neosetophomone_B_by_targeting_AKT_SKP2_MTH1_axis_in_leukemic_cells/24745794 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Oncology and carcinogenesis Natural products Meroterpenoids Fungal secondary metabolites Neosetophomone B Apoptosis Leukemia |
| dc.title.none.fl_str_mv | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggered by mitochondrial signaling and caspase activation. Additionally, NSP-B treatment of leukemic cells causes AKT's inactivation accompanied by downregulation of SKP2 oncogene and MTH1 with a concomitant increase of p21Cip1and p27Kip1. Furthermore, NSP-B causes suppression of antiapoptotic proteins, including cIAP1, cIAP2, XIAP, survivin and BCl-XL. Overall, NSP-B reduces cell viability by mitochondrial and caspase-dependent apoptosis. The inhibition of AKT and SKP2 axis could be a promising therapeutic target for leukemia treatment.</p><h2>Other Information</h2> <p> Published in: Biochemical and Biophysical Research Communications<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbrc.2022.02.071" target="_blank">https://dx.doi.org/10.1016/j.bbrc.2022.02.071</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_199858fab464217cd2a1c2efa96b7cbd |
| identifier_str_mv | 10.1016/j.bbrc.2022.02.071 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24745794 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cellsShilpa Kuttikrishnan (3520079)Ajaz A. Bhat (12984701)Jericha M. Mateo (17563293)Fareed Ahmad (134672)Feras Q. Alali (2691907)Tamam El-Elimat (694398)Nicholas H. Oberlies (326437)Cedric J. Pearce (1364220)Shahab Uddin (154400)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesCardiovascular medicine and haematologyOncology and carcinogenesisNatural productsMeroterpenoidsFungal secondary metabolitesNeosetophomone BApoptosisLeukemia<p>Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggered by mitochondrial signaling and caspase activation. Additionally, NSP-B treatment of leukemic cells causes AKT's inactivation accompanied by downregulation of SKP2 oncogene and MTH1 with a concomitant increase of p21Cip1and p27Kip1. Furthermore, NSP-B causes suppression of antiapoptotic proteins, including cIAP1, cIAP2, XIAP, survivin and BCl-XL. Overall, NSP-B reduces cell viability by mitochondrial and caspase-dependent apoptosis. The inhibition of AKT and SKP2 axis could be a promising therapeutic target for leukemia treatment.</p><h2>Other Information</h2> <p> Published in: Biochemical and Biophysical Research Communications<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.bbrc.2022.02.071" target="_blank">https://dx.doi.org/10.1016/j.bbrc.2022.02.071</a></p>2022-04-23T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.bbrc.2022.02.071https://figshare.com/articles/journal_contribution/Anticancer_activity_of_Neosetophomone_B_by_targeting_AKT_SKP2_MTH1_axis_in_leukemic_cells/24745794CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247457942022-04-23T06:00:00Z |
| spellingShingle | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells Shilpa Kuttikrishnan (3520079) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Oncology and carcinogenesis Natural products Meroterpenoids Fungal secondary metabolites Neosetophomone B Apoptosis Leukemia |
| status_str | publishedVersion |
| title | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells |
| title_full | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells |
| title_fullStr | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells |
| title_full_unstemmed | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells |
| title_short | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells |
| title_sort | Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology Oncology and carcinogenesis Natural products Meroterpenoids Fungal secondary metabolites Neosetophomone B Apoptosis Leukemia |