The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling

The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling

<p dir="ltr">The E3 ubiquitin-ligase UHRF1 is an epigenetic regulator coordinating DNA methylation and histone modifications. However, little is known about how it regulates adipogenesis or metabolism. In this study, we discovered that UHRF1 is a key regulatory factor for adipogenesi...

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Bibliographic Details
Main Author: Muneera Vakayil (12037693) (author)
Other Authors: Aisha Y. Madani (14152911) (author), Maha V. Agha (7956170) (author), Yasser Majeed (9417974) (author), Shahina Hayat (8774135) (author), Shameem Yonuskunju (18870850) (author), Yasmin Ali Mohamoud (6053681) (author), Joel Malek (3497978) (author), Karsten Suhre (67967) (author), Nayef A. Mazloum (7355087) (author)
Published: 2024
Subjects:
Biological sciences
Biochemistry and cell biology
Biomedical and clinical sciences
Medical biochemistry and metabolomics
Cell biology
Molecular biology
Obesity
Inflammation
Metabolic disorders
Insulin sensitivity
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