Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors

<h3>Aims/hypothesis</h3><p dir="ltr">Homozygous mutations in <i>RFX6</i> lead to neonatal diabetes accompanied by a hypoplastic pancreas, whereas heterozygous mutations cause MODY. Recent studies have also shown <i>RFX6</i> variants to be linked wi...

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Bibliographic Details
Main Author: Noura Aldous (15429873) (author)
Other Authors: Ahmed K. Elsayed (13275302) (author), Bushra Memon (4792767) (author), Sadaf Ijaz (10992855) (author), Sikander Hayat (35163) (author), Essam M. Abdelalim (5768072) (author)
Published: 2024
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Medical biochemistry and metabolomics
Paediatrics
Diabetes
Endocrine specification
Islet organoids
Pancreatic hypoplasia
Pancreatic progenitors
Transcription factors
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