Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
<h3>Aims/hypothesis</h3><p dir="ltr">Homozygous mutations in <i>RFX6</i> lead to neonatal diabetes accompanied by a hypoplastic pancreas, whereas heterozygous mutations cause MODY. Recent studies have also shown <i>RFX6</i> variants to be linked wi...
محفوظ في:
| المؤلف الرئيسي: | Noura Aldous (15429873) (author) |
|---|---|
| مؤلفون آخرون: | Ahmed K. Elsayed (13275302) (author), Bushra Memon (4792767) (author), Sadaf Ijaz (10992855) (author), Sikander Hayat (35163) (author), Essam M. Abdelalim (5768072) (author) |
| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
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مواد مشابهة
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PDX1<sup>−</sup>/NKX6.1<sup>+</sup> progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells
حسب: Bushra Memon (4792767)
منشور في: (2020) -
Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors
حسب: Idil I. Aigha (14913774)
منشور في: (2018) -
NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation
حسب: Idil I. Aigha (14913774)
منشور في: (2020) -
Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
حسب: Bushra Memon (4792767)
منشور في: (2018) -
Correction to: Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
حسب: Bushra Memon (4792767)
منشور في: (2018)