In vitro modeling of GCK mutation-associated monogenic diabetes using human iPSC and gene-editing technologies

In vitro modeling of GCK mutation-associated monogenic diabetes using human iPSC and gene-editing technologies

<p><strong>Poster by Yasmin Abu Aqel (Hamad Bin Khalifa University), Racha Chouaib (Hamad Bin Khalifa University), Aldana I. Alnesf (Hamad Bin Khalifa University), Idil Ahmed (Hamad Bin Khalifa University), Gowher Ali (Hamad Bin Khalifa University), Ahmed K. Elsayed (Hamad Bin Khalifa Un...

Full description

Saved in:

Bibliographic Details
Main Author:	Yasmin Abu Aqel (15430057) (author)
Other Authors:	Racha Chouaib (15430058) (author), Aldana I. Alnesf (15430061) (author), Idil Ahmed (10235801) (author), Gowher Ali (14152593) (author), Ahmed K. Elsayed (13275302) (author), Zeyaul Islam (5867387) (author), Sara Al-Khawaga (4792761) (author), Prasanna R. KolatkarV (15430063) (author), Paul J. Thornalley (14590926) (author), Khalid Hussain (7093571) (author), Essam M. Abdelalim (14152596) (author)
Published:	2023
Subjects:	Medical biotechnology Induced Pluripotent Stem Cells Glucokinase Pancreatic β-cells CRISPR/Cas9 Maturity‐Onset Diabetes of the Young 2
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Rapid Assessment of CRISPR Transfection Efficiency and Enrichment of CRISPR Induced Mutations Using a Dual-Fluorescent Stable Reporter System
by: Karim E. Shalaby (12267224)
Published: (2022)

LncRNA-Based Classification of Triple Negative Breast Cancer Revealed Inherent Tumor Heterogeneity and Vulnerabilities
by: Radhakrishnan Vishnubalaji (3563306)
Published: (2022)

Genome-wide differential expression profiling of long non-coding RNAs in FOXA2 knockout iPSC-derived pancreatic cells
by: Ahmed K. Elsayed (13275302)
Published: (2023)

CRISPR FokI Dead Cas9 System: Principles and Applications in Genome Engineering
by: Maryam Saifaldeen (12561970)
Published: (2020)

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
by: Maryam Aghadi (17128819)
Published: (2022)

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation
by: Idil I. Aigha (14913774)
Published: (2020)

Identification of potential transcription factors that enhance human iPSC generation
by: Nuha T. Swaidan (18595219)
Published: (2020)

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
by: Noura Aldous (15429873)
Published: (2023)

Identifying miRNA Signatures Associated with Pancreatic Islet Dysfunction in a FOXA2-Deficient iPSC Model
by: Ahmed K. Elsayed (13275302)
Published: (2024)

Genetic engineering to enhance microalgal-based produced water treatment with emphasis on CRISPR/Cas9: A review
by: Alaa Hassanien (19420603)
Published: (2023)

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
by: Noura Aldous (15429873)
Published: (2023)

Characterization of a loss-of-function NSF attachment protein beta mutation in monozygotic triplets affected with epilepsy and autism using cortical neurons from proband-derived and CRISPR-corrected induced pluripotent stem cell lines
by: Gowher Ali (14152593)
Published: (2024)

Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene
by: Yasmin W. Abu Aqel (17100289)
Published: (2020)

Application of CRISPR/Cas gene editing for infectious disease control in poultry
by: Mahdi Gallala (22457734)
Published: (2025)

The Genetic Spectrum of Maturity-Onset Diabetes of the Young (MODY) in Qatar, a Population-Based Study
by: Asma A. Elashi (17821415)
Published: (2022)

Preclinical Evaluation of Human Pluripotent Stem Cells-Derived Pancreatic Progenitor Cells (hPSCs-PPs) Using Transgenic Zebrafish Models
by: Zahra Morshed (15430067)
Published: (2023)

Tissue-Specific Delivery of CRISPR Therapeutics: Strategies and Mechanisms of Non-Viral Vectors
by: Karim Shalaby (18718678)
Published: (2020)

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors
by: Idil I. Aigha (14913774)
Published: (2018)

Editorial: Transdetermination, transdifferentiation, and reprogramming of cells: In vitro and in vivo strategies
by: Artur Cieslar-Pobuda (18222593)
Published: (2023)

CRISPR-Cas Controls Cryptic Prophages
by: Sooyeon Song (4891132)
Published: (2022)

Epigenetic memory as crucial contributing factor in directing the differentiation of human iPSC into pancreatic β-cells in vitro
by: Abdoulaye Diane (14152749)
Published: (2025)

Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A meta-analysis
by: Toqa Darwish (13222230)
Published: (2022)

β-cell mitochondria in diabetes mellitus: a missing puzzle piece in the generation of hPSC-derived pancreatic β-cells?
by: Abdoulaye Diane (14152749)
Published: (2022)

Understanding the Mechanism of Dysglycemia in a Fanconi-Bickel Syndrome Patient
by: Sanaa Sharari (12561952)
Published: (2022)

Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons
by: Seema C. Namboori (11031624)
Published: (2021)

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
by: Shadi Nejat (19457212)
Published: (2023)

PDX1<sup>−</sup>/NKX6.1<sup>+</sup> progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells
by: Bushra Memon (4792767)
Published: (2020)

Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors
by: Bushra Memon (4792767)
Published: (2020)

Conserved genes regulating human sex differentiation, gametogenesis and fertilization
by: Khalid A. Fakhro (3158862)
Published: (2024)

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
by: Noura Aldous (15429873)
Published: (2024)

Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era
by: Ammira Al-Shabeeb Akil (15143925)
Published: (2021)

Islets in the body are never flat: transitioning from two-dimensional (2D) monolayer culture to three-dimensional (3D) spheroid for better efficiency in the generation of functional hPSC-derived pancreatic β cells in vitro
by: Abdoulaye Diane (14152749)
Published: (2023)

Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas
by: Abu Saleh Md Moin (6189512)
Published: (2019)

CRISPR-Based Multiplex Detection of Human Papillomaviruses for One-Pot Point-of-Care Diagnostics
by: Ahmed Ghouneimy (17959417)
Published: (2024)

Genome-wide differential expression profiling of long non-coding RNAs (lncRNAs) in pancreatic cells derived from FOXA2-/- iPSCs
by: Ahmed K. Elsayed (13275302)
Published: (2023)

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-derived β-cells
by: Abdoulaye Diane (14152749)
Published: (2023)

Enhanced generation of beta cell precursors and functional insulin-secreting cells from human pluripotent stem cells
by: Bushra Memon (4792767)
Published: (2023)

Effective generation of functional pancreatic β-cells from human derived dental stem cells of apical papilla and bone marrow derived stem cells
by: Duaa Abuarqoub (6672434)
Published: (2023)

A CRISPR-based approach using dead Cas9-sgRNA to detect SARS-CoV-2
by: Mustapha Aouida (417652)
Published: (2023)

Transcription Factors: The Fulcrum Between Cell Development and Carcinogenesis
by: Zeyaul Islam (5867387)
Published: (2021)

Cannot write session to /tmp/vufind_sessions/sess_89k0gcpeq13bdmfdgtp9cfn6ol