Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A meta-analysis

Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A meta-analysis

<h3>Introduction</h3><p dir="ltr">Cystic fibrosis (CF) is a hereditary autosomal recessive disorder caused by a range of mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. This gene encodes the CFTR protein, which acts as a chloride channel activated by...

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Main Author: Toqa Darwish (13222230) (author)
Other Authors: Azhar Al-Khulaifi (13222233) (author), Menatalla Ali (13222236) (author), Rana Mowafy (13222239) (author), Abdelilah Arredouani (10914455) (author), Suhail A. Doi (9552474) (author), Mohamed M. Emara (9913215) (author)
Published: 2022
Subjects:
Biological sciences
Genetics
Zoology
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Medical biochemistry and metabolomics
Medical biotechnology
Mathematical sciences
Statistics
Cystic Fibrosis (CF)
Autosomal recessive disorder
CFTR gene
CFTR protein
Respiratory disease
Pathogens
Respiratory failure
Liver, pancreas, small bowel
Molecular mechanisms
Disease modeling
Animal models
iPSC (Induced Pluripotent Stem Cells)
Amyotrophic lateral sclerosis (ALS)
Spinal muscular atrophy (SMA)
Parkinson’s disease (PD)
Alzheimer’s disease (AD)
Drug responses
Chloride channel function
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