Aspirin inhibition and recovery of cyclooxygenase activity and thromboxane biosynthesis in human megakaryocytes: a translational surrogate model

Aspirin inhibition and recovery of cyclooxygenase activity and thromboxane biosynthesis in human megakaryocytes: a translational surrogate model

<p dir="ltr">Low-dose aspirin irreversibly acetylates cyclooxygenase (COX)-1 in anucleate platelets and progenitor megakaryocytes, permanently suppressing thromboxane (TX)A<sub>2</sub>-dependent platelet activation. Although aspirin pharmacodynamics is well characterized...

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Bibliographic Details
Main Author: Zahraa I. Mallah (23125621) (author)
Other Authors: Giovanna Petrucci (268797) (author), Abeer J. Ayoub (9449147) (author), Mohammad A. Farhoud (23125624) (author), Joseph G. Jelwan (23125627) (author), Sara Lucchisani (23125630) (author), Adham K. Fakih (23125633) (author), Bassam Badran (215585) (author), Eva Hamade (584190) (author), Carlo Patrono (15106379) (author), Bianca Rocca (6330692) (author), Aida Habib (6686057) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Pharmacology and pharmaceutical sciences
Megakaryocytes
Cyclooxygenase-1
Thromboxane
Aspirin
Platelets
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