From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease

<p dir="ltr">Type 2 Diabetes (T2D) and Alzheimer’s Disease (AD) share common risk factors that can be seen through T2D nearly doubling an individual’s likelihood of developing AD. Some AD patients show signs of metabolic dysfunction as well. This review focuses on the potential mecha...

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Bibliographic Details
Main Author:	Ahmad Raza (18205961) (author)
Other Authors:	Shafaq Saleem (22934654) (author), Samar Imran (22997221) (author), Sarah Rahman (4568125) (author), Muhammad Haroon (7830661) (author), Azeen Razzaq (22997224) (author), Ahmad Hussain (22997227) (author), Javed Iqbal (2121922) (author), Brijesh Sathian (479264) (author)
Published:	2025
Subjects:	Biomedical and clinical sciences Medical biochemistry and metabolomics Neurosciences Type 2 diabetes mellitus (T2D) Alzheimer’s disease (AD) Insulin resistance Amyloid-beta (Aβ) accumulation Advanced glycation end products (AGEs) Neuroinflammation Mitochondrial dysfunction
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From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease

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