Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene
<p dir="ltr">Heterozygous and homozygous mutations in the <i>glucokinase</i> (<i>GCK</i>) gene leads to maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes (PNDM), respectively. Here, we report the generation of two induced plur...
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2020
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| _version_ | 1864513511241023488 |
|---|---|
| author | Yasmin W. Abu Aqel (17100289) |
| author2 | Gowher Ali (14152593) Ahmed K. Elsayed (13275302) Sara Al-Khawaga (4792761) Khalid Hussain (110443) Essam M. Abdelalim (5768072) |
| author2_role | author author author author author |
| author_facet | Yasmin W. Abu Aqel (17100289) Gowher Ali (14152593) Ahmed K. Elsayed (13275302) Sara Al-Khawaga (4792761) Khalid Hussain (110443) Essam M. Abdelalim (5768072) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yasmin W. Abu Aqel (17100289) Gowher Ali (14152593) Ahmed K. Elsayed (13275302) Sara Al-Khawaga (4792761) Khalid Hussain (110443) Essam M. Abdelalim (5768072) |
| dc.date.none.fl_str_mv | 2020-10-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.scr.2020.101991 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Generation_of_two_human_iPSC_lines_from_patients_with_maturity-onset_diabetes_of_the_young_type_2_MODY2_and_permanent_neonatal_diabetes_due_to_mutations_in_the_GCK_gene/24249922 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Clinical sciences diabetes PNDM stem cell gene |
| dc.title.none.fl_str_mv | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Heterozygous and homozygous mutations in the <i>glucokinase</i> (<i>GCK</i>) gene leads to maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes (PNDM), respectively. Here, we report the generation of two induced pluripotent stem cell (iPSC) lines, QBRIi010-A and QBRIi011-A, from patients with MODY2 and PNDM due to mutations in the <i>GCK</i> gene (c.437 T > C). The generated iPSC lines displayed pluripotency characteristics, were able to differentiate into the three germ layers, and showed normal karyotypes. These iPSC lines will serve as valuable human cell models for understanding diabetes pathogenesis and developing new therpaies for diabetes.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.scr.2020.101991" target="_blank">https://dx.doi.org/10.1016/j.scr.2020.101991</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_2d22a54a615dd5862f082403c6d7c545 |
| identifier_str_mv | 10.1016/j.scr.2020.101991 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24249922 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK geneYasmin W. Abu Aqel (17100289)Gowher Ali (14152593)Ahmed K. Elsayed (13275302)Sara Al-Khawaga (4792761)Khalid Hussain (110443)Essam M. Abdelalim (5768072)Biological sciencesBiochemistry and cell biologyGeneticsBiomedical and clinical sciencesClinical sciencesdiabetesPNDMstem cellgene<p dir="ltr">Heterozygous and homozygous mutations in the <i>glucokinase</i> (<i>GCK</i>) gene leads to maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes (PNDM), respectively. Here, we report the generation of two induced pluripotent stem cell (iPSC) lines, QBRIi010-A and QBRIi011-A, from patients with MODY2 and PNDM due to mutations in the <i>GCK</i> gene (c.437 T > C). The generated iPSC lines displayed pluripotency characteristics, were able to differentiate into the three germ layers, and showed normal karyotypes. These iPSC lines will serve as valuable human cell models for understanding diabetes pathogenesis and developing new therpaies for diabetes.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.scr.2020.101991" target="_blank">https://dx.doi.org/10.1016/j.scr.2020.101991</a></p>2020-10-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.scr.2020.101991https://figshare.com/articles/journal_contribution/Generation_of_two_human_iPSC_lines_from_patients_with_maturity-onset_diabetes_of_the_young_type_2_MODY2_and_permanent_neonatal_diabetes_due_to_mutations_in_the_GCK_gene/24249922CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242499222020-10-01T00:00:00Z |
| spellingShingle | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene Yasmin W. Abu Aqel (17100289) Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Clinical sciences diabetes PNDM stem cell gene |
| status_str | publishedVersion |
| title | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene |
| title_full | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene |
| title_fullStr | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene |
| title_full_unstemmed | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene |
| title_short | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene |
| title_sort | Generation of two human iPSC lines from patients with maturity-onset diabetes of the young type 2 (MODY2) and permanent neonatal diabetes due to mutations in the GCK gene |
| topic | Biological sciences Biochemistry and cell biology Genetics Biomedical and clinical sciences Clinical sciences diabetes PNDM stem cell gene |