Understanding the Mechanism of Diabetes Mellitus in a LRBA-Deficient Patient

Understanding the Mechanism of Diabetes Mellitus in a LRBA-Deficient Patient

<div><p>The scope of this study is to show that DM in a LRBA-deficient patient with a stop codon mutation (c.3999 G > A) was not mediated through autoimmunity. We have evaluated the ability of the proband’s T cells to be activated by assessing their CTLA-4 expression. A nonsignificant...

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Bibliographic Details
Main Author: Iman Hawari (12561958) (author)
Other Authors: Johan Ericsson (49714) (author), Basirudeen Syed Ahamed Kabeer (9676280) (author), Damien Chaussabel (26369) (author), Asma Alsulaiti (18281824) (author), Sanaa A. Sharari (18281827) (author), Cristina Maccalli (2632465) (author), Faiyaz Ahmad Khan (18281830) (author), Khalid Hussain (110443) (author)
Published: 2022
Subjects:
Agricultural, veterinary and food sciences
Agricultural biotechnology
Biological sciences
Biochemistry and cell biology
Biomedical and clinical sciences
Immunology
diabetes mellitus
autoimmunity
LRBA
CTLA-4
blood transcriptomics
insulin secretion
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