A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

<p dir="ltr">Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived metabolites, in this process. LC/MS lipidomic sc...

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Bibliographic Details
Main Author: Ahmed S. Ibrahim (10049522) (author)
Other Authors: Sally Elshafey (18806887) (author), Hassan Sellak (842314) (author), Khaled A. Hussein (18806890) (author), Mohamed El-Sherbiny (8830880) (author), Mohammed Abdelsaid (6184889) (author), Nasser Rizk (380137) (author), Selina Beasley (18806893) (author), Amany M. Tawfik (18806896) (author), Sylvia B. Smith (7435550) (author), Mohamed Al-Shabrawey (380138) (author)
Published: 2015
Subjects:
Biomedical and clinical sciences
Clinical sciences
Medical biochemistry and metabolomics
diabetic retinopathy
12- and 15-HETEs
retinal vascular leakage
reduced nicotinamide adenine dinucleotide phosphate oxidase
retinal inflammation
ipoxygenase
bioactive lipids
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