Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

<h3>Background</h3><p dir="ltr">Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. We investigated the role o...

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Bibliographic Details
Main Author: Muhanad Alhujaily (11630107) (author)
Other Authors: Hafsa Abbas (9501821) (author), Mingzhan Xue (3607649) (author), Alberto de la Fuente (360936) (author), Naila Rabbani (291722) (author), Paul J. Thornalley (291723) (author)
Published: 2021
Subjects:
Biomedical and clinical sciences
Oncology and carcinogenesis
methylglyoxal
glyoxalase
cancer chemotherapy
multidrug resistance
proteomics
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