DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

<p dir="ltr">Sox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal...

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Bibliographic Details
Main Author: Kamesh Narasimhan (2191165) (author)
Other Authors: Shubhadra Pillay (2191162) (author), Yong-Heng Huang (14114952) (author), Sriram Jayabal (19020227) (author), Barath Udayasuryan (19547716) (author), Veeramohan Veerapandian (12080201) (author), Prasanna Kolatkar (7532792) (author), Vlad Cojocaru (9672) (author), Konstantin Pervushin (248559) (author), Ralf Jauch (173035) (author)
Published: 2015
Subjects:
Biological sciences
Bioinformatics and computational biology
Genetics
Biomedical and clinical sciences
Clinical sciences
Genomics
Cis-regulatory code
Enhancer DNA sequences
Epigenetic signatures
Neurogenesis
DNA-binding motifs
Gene expression regulation
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