Ivabradine, a hyperpolarization-activated channel blocker, attenuates mechanical, but not heat, hypersensitivity in hyperglycaemic and normoglycemic rat models of diabetic neuropathy

Ivabradine, a hyperpolarization-activated channel blocker, attenuates mechanical, but not heat, hypersensitivity in hyperglycaemic and normoglycemic rat models of diabetic neuropathy

<p dir="ltr">Diabetic peripheral neuropathic pain (DPNP) is a debilitating complication of longstanding type 1 (T1DM) and type 2 (T2DM) diabetes mellitus. DPNP patients experience mechanical and thermal pain hypersensitivity. Despite its clinical significance and high prevalence, tre...

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Bibliographic Details
Main Author: Dina Elsayegh (23739912) (author)
Other Authors: Omar Tluli (23739915) (author), Maram Elzayyat (22928644) (author), Abdelrahman Karen (23739918) (author), Layan Albarghouthi (23739921) (author), Abdulla Al-Emadi (23739924) (author), Mubarak AlMaadid (23739927) (author), Haya Al-Mohannadi (20362818) (author), Laiche Djouhri (112613) (author)
Published: 2025
Subjects:
Biomedical and clinical sciences
Medical biochemistry and metabolomics
Neurosciences
Pharmacology and pharmaceutical sciences
Diabetic peripheral neuropathy
neuropathic pain
pain hypersensitivity
hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
ivabradine
mechanical allodynia
thermal hyperalgesia
streptozotocin (STZ)
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