Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia

Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia

<p dir="ltr">Protein tyrosine phosphatase receptor type γ (PTPRG) is a tumor suppressor gene, down-regulated in Chronic Myeloid Leukemia (CML) cells by the hypermethylation of its promoter region. β-catenin (CTNNB1) is a critical regulator of Leukemic Stem Cells (LSC) maintenance and...

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Bibliographic Details
Main Author: Luisa Tomasello (702932) (author)
Other Authors: Marzia Vezzalini (212801) (author), Christian Boni (11729021) (author), Massimiliano Bonifacio (304529) (author), Luigi Scaffidi (12828062) (author), Mohamed Yassin (4166515) (author), Nader Al-Dewik (4166527) (author), Paul Takam Kamga (18561280) (author), Mauro Krampera (292581) (author), Claudio Sorio (212799) (author)
Published: 2020
Subjects:
Biological sciences
Biochemistry and cell biology
Genetics
Biomedical and clinical sciences
Clinical sciences
Oncology and carcinogenesis
β-catenin
PTPRG
chronic myeloid leukemia
methylation
tumor suppressor
tyrosine phosphatase
DNMT
5-azacytidine
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