Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers

<div><p>The aggregation of α-synuclein (α-syn) into neurotoxic oligomers and fibrils is an important pathogenic feature of synucleinopatheis, including Parkinson’s disease (PD). A further characteristic of PD is the oxidative stress that results in the formation of aldehydes by lipid per...

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Bibliographic Details
Main Author: Nishant Vaikath (3554687) (author)
Other Authors: Indulekha Sudhakaran (18394761) (author), Ilham Abdi (18394764) (author), Vijay Gupta (209146) (author), Nour Majbour (3528548) (author), Simona Ghanem (8548050) (author), Houari Abdesselem (14152914) (author), Kostas Vekrellis (214282) (author), Omar El-Agnaf (2134222) (author)
Published: 2022
Subjects:
Chemical sciences
Inorganic chemistry
Organic chemistry
Physical chemistry
Theoretical and computational chemistry
alpha-synuclein
oligomers
HNE
ONE
DA
Parkinson’s disease
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